| ncRNA name | MMP-9 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell line HXO-RB44 |
| Methods | siRNA transfection, qPCR, Western blot, transwell assay, luciferase reporter assay |
| Expression pattern | associated |
| Functional description | HIF-1α and MMP9 in cells transfected by HIF1α siRNA, were significantly decreased, and the difference had statistical significance (p < 0.05); there were no remarkable changes in mRNA and protein expressions of HIF-1α in cells transfected by MMP9-specific siRNA, but the mRNA and protein expressions of MMP9 were significantly reduced, and the difference had statistical significance (p < 0.05). |
| PubMed ID | 29243776 |
| Year | 2017 |
| Title | Hypoxia promotes invasion of retinoblastoma cells in vitro by upregulating HIF-1α/MMP9 signaling pathway. |
| Drug-related ncRNA | NO |
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